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Despite its relatively young age it has already established itself as a top gaming platform for casinos. Wolves is one of the latest games which is a five-reel slot machine that has a high RTP and stunning graphics. Its other notable titles are Wolf Gold and Chilli Heat. The goal of pragmatic trials is to mimic real-life scenarios and gain maximum credibility externally. They are usually requested by policy makers and practitioners to inform their decision making. They can be used to determine the cause-effect relationship of an intervention with its outcomes. However, they should not be used in lieu for the use of explanation trials. The pragmatism idea is controversial and there are concerns about whether pragmatic trials can replace explanatory tests or if they are an addition to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials, which guide policy and practice decisions. They also proposed a framework for pragmatic trials, which they called PRECIS.2 This tool attempted to define the characteristics of a pragmatic trial that include the recruitment process, the design and implementation of the intervention, and monitoring. There is a positive increase in the number pragmatic trials that are published. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs), yielded 34 articles, which are shown in red in Figure 2. This is a sign that the health science community is becoming more acquaint to the subject of pragmatism. It is important to note that the majority of these trials were conducted in primary care settings.